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Aerial view of UCSD campus looking South

Geisel Library - Nobel Laureates at UCSD

Discovery of new atmospheric reaction garners prize

Urey Hall Addition

Pacific Hall

Natural Sciences Building

The crystal structure of a group II intron in the pre-catalytic state

Geisel Library Walk

York Hall

Structure of an inhibitor of hepatitis C virus protein synthesis bound to its target in the viral ribonucleic acid (RNA) genome

ANCA probe staining amyloid plaques derived from Alzheimer’s-related Aβ peptides fluoresces as green and as yellow when derived from prion proteins (PrPSC)

Price Center

Generation of bio-resistive surface coatings on amyloids inhibits harmful protein-amyloid interactions associated with Alzheimer disease

Proposed schematic models of the interfacial binding surface of four different members of the Phospholipase A2 superfamily

Urey Hall and Pacific Hall

Characterization of the "inhibitor binding pocket" in the catalytic domain of the calcium-independent phospholipase A2 with residues within a 5 A raidus of the inhibitor shown

A Crystalline Singlet Phosphinonitrene: a Nitrogen Atom Transfer Agent

Mayer Hall

Drug candidate in orange envelope bound to UPPS

Possible binding modes for phospholipase A2 via its membrane interaction site, another allosteric site, and its catalytic site



News

Gianneschi Group Consortiums Awarded $13.3 Million in Research Grants from DOD MURI Program
The Gianneschi Group in the Department of Chemistry & Biochemistry at UC San Diego is a key member of two university consortiums awarded research grants totaling $13.3 Million by the U.S. Department of Defense (DOD) Multi-Disciplinary University Research Initiative (MURI) Program. The awards include a $7 million grant from the Air Force Office of Scientific Research (AFOSR) to support research developing 3D-printing technologies at nanoscale levels and a $6.3 Million grant from the Army Research Office (ARO) to support research into materials capable of performing as autonomous sense-and-response systems.

Distinguished Professor Michael Sailor Named a Fellow of the National Academy of Inventors
The National Academy of Inventors announced the election of Michael Sailor, Distinguished Professor of Chemistry and Biochemistry at UC San Diego, as a member of its 2015 class of new fellows. The distinction honors academic inventors whose work has made a tangible impact on the quality of life, economic development and the welfare of society. Fellows are nominated by their peers and must be named inventors on U.S. Patents. Professor Sailor is a leader in silicon nanotechnology focusing on the structure of porous silicon on a nanometer scale to address a wide array of potential applications such as targeted delivery of powerful therapeutics to rechargeable batteries with higher capacity and longer life. Dr. Sailor holds 26 patents. Congratulations Professor Sailor.

Professor Kamil Godula Receives NIH Director's New Innovator Award
Kamil Godula, an assistant professor in the Department of Chemistry and Biochemistry at UC San Diego, was named a recipient of the National Institutes of Health (NIH) Director's New Innovator Award. The Award is part of the NIH's High-Risk, High-Reward Research program that supports exceptionally creative, early career investigators who propose innovative high-impact projects. The $2.3 million multi-year New Innovator Award will support Professor Godula's research developing chemical approaches and nanotechnologies to study how spatial arrangements of glycans on cell-surface proteins encode biological information and how this information can be harnessed to control the outcomes of cellular differentiation.

UC San Diego's Environmental and Earth Sciences Ranked 1st in the U.S. by the science journal Nature
The science journal, Nature, ranked UC San Diego the top institution in the U.S., and fourth in the world, for Environmental and Earth Sciences, based on published research. The rankings of institutions for high-quality science are based on the Nature Index, a weighted fractional count of articles appearing in 68 natural science journals. UC San Diego was ranked fifth in the U.S., and 14th in the world, in all science categories combined.

Devaraj Lab Designs New Method to Tag RNA
A team of researchers from Professor Neal Devaraj's Lab in the Department of Chemistry and Biochemistry at UC San Diego have developed a versatile new method for tagging RNA. The team used a bacterial enzyme that recognizes a specific hairpin turn in RNA to make their tagging system. Using chemical links, they developed a system that can attach a variety of molecules to PreQ on the outer curve of the hairpin turn, so that the RNA is tagged with something useful, such as fluorescent die or a molecular handle that allows the visualization within the cell. Their research article was recently published in the Journal of the American Chemical Society. To view the full research article click here

Professor Wei Xiong Receives DARPA 2015 Young Faculty Award
Wei Xiong, an assistant professor in the Department of Chemistry and Biochemistry at UC San Diego, has received the Defense Advanced Research Projects Agency (DARPA) 2015 Young Faculty Award (YFA). The award provides funding of up to $1 million to further Dr. Xiong's research developing new spectroscopic techniques for observing ultrafast processes in nanomaterials, more specifically, revealing the relationship between molecular conformation and charge separation dynamics in nano-energy materials by surface sensitive multidimensional spectroscopy.

Professor Rommie Amaro to Lead New Consortium Launched by UC San Diego & TSRI to Create Virtual Cell
UC San Diego and The Scripps Research Institute (TSRI) announced the formation of The Visible Molecular Cell Consortium (VMCC), a collaborative effort to assemble and simulate a virtual model of a cell. Rommie Amaro, professor of chemistry and biochemistry at UC San Diego and Arthur Olson, professor of molecular biology at TSRI, will jointly direct the consortium. The collaboration leverages existing strengths at both institutions to create 3D virtual cells down to the atomic level of detail. VMCC will offer fellowship funding for a dozen graduate students and postdoctoral fellows to work on collaborative projects across multiple disciplines that build bridges between the campuses. Organizers believe insights into cellular behavior gained from the collaboration will be applicable across many scientific fields. Directors' Amaro and Olson have scheduled their first workshop for Friday, October 2, 2015. Researchers interested in learning more about the consortium can direct inquiries to visiblemolecularcell@gmail.com.

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Message from the Chair

Partho Ghosh, Chair



Faculty Spotlight

View profile for Kim Albizati
Kim Albizati

Chemical Education

View profile for Rommie Amaro
Rommie Amaro

Computational Chemistry and Biophysics

View profile for Timothy Baker
Timothy Baker

Macromolecular, cryoelectron microscopy and three-dimensional, image-reconstruction techniques.

View profile for Stacey Brydges
Stacey Brydges

Chemical Education: Development of context-rich curriculum; Use of collaborative learning strategies in large lectures; Communication of chemistry

View profile for Michael Burkart
Michael Burkart

Natural product synthesis/biosynthesis, Biological chemistry and enzymology, Metabolic engineering.

View profile for Thomas Bussey
Thomas Bussey

Chemical Education: Visual Literacy in Science, Biochemistry Education, Nano Science Education, K-20 Professional Development, and STEM Career Development

View profile for Seth Cohen
Seth Cohen

Bioinorganic and coordination chemistry. Metalloprotein inhibitors and supramolecular materials.

View profile for Robert Continetti
Robert Continetti

Dissociation dynamics of transient species, three-body reaction dynamics, novel mass-spectrometric methods

View profile for John Crowell
John Crowell

Materials chemistry, surface kinetics of metals/semiconductors, CVD, photo-induced deposition, thin-film spectroscopy.

View profile for Edward Dennis
Edward Dennis

Biochemistry: phospholipase A2, signal transduction in macrophages, lipid maps, prostaglandin regulation, mass spec of lipids and proteins.

View profile for Neal Devaraj
Neal Devaraj

Biomimetic Chemistry, Molecular Imaging, Chemical Biology

View profile for Jack Dixon
Jack Dixon

Protein Tyrosine Phosphatase, Dual=specific Phosphatase, PTEN

View profile for Daniel Donoghue
Daniel Donoghue

Fibroblast Growth Factor Receptors (FGFRs) in Human Cancer

View profile for Joshua Figueroa
Joshua Figueroa

Inorganic and Organometallic Chemistry: Synthesis, Small Molecule Activation and New Transformations.

View profile for Michael Galperin
Michael Galperin

Electron Transport in Condensed Phases. Dissipation and Relaxation Processes. Non-equilibrium Open Quantum Systems. Molecular Electronics.

View profile for Gourisankar Ghosh
Gourisankar Ghosh

Biochemistry and biophysics: transcription, signaling, pre-mRNA splicing, mRNA transport, protein-protein, protein-DNA and protein-RNA interactions

View profile for Partho Ghosh
Partho Ghosh

Mechanisms of bacterial and protozoan pathogenesis, and host response against infectious microbes.

View profile for Nathan Gianneschi
Nathan Gianneschi

Bioorganic chemistry, Supramolecular Chemistry, Bionanotechnology, Materials, Synthesis

View profile for Kamil Godula
Kamil Godula

Nanotechnologies for analysis of glycan function during development. Glycomaterials for stem cell-based tissue regeneration.

View profile for Vicki Grassian
Vicki Grassian

Surface science of complex environmental interfaces: heterogeneous atmospheric chemistry of sea spray and mineral dust; aerosol impacts on climate; applications and implications of nanoscience and nanotechnology in environmental processes and health.

View profile for Thomas Hermann
Thomas Hermann

RNA as a Drug Target.

View profile for Patricia Jennings
Patricia Jennings

Biophysical chemistry: protein structure, dynamics and folding; 2, 3 and 4D NMR spectroscopy; PCR; equilibrium and kinetic-fluorescence, absorbance and circular dichroism spectroscopies

View profile for Simpson Joseph
Simpson Joseph

Molecular Mechanism of Protein Synthesis

View profile for Judy Kim
Judy Kim

Biophysical chemistry: Spectroscopic studies of membrane protein folding and dynamics

View profile for Elizabeth Komives
Elizabeth Komives

Structure, function, dynamics and thermodynamics of protein-protein interactions: NMR, mass spectrometry and kinetics

View profile for Clifford Kubiak
Clifford Kubiak

Inorganic, materials, and physical chemistry: electron transfer, catalysis, fixation and utilization of carbon dioxide.

View profile for Andrew Kummel
Andrew Kummel

STM/STS of gate oxides on compound semiconductors and adsorbates on organic semiconductor

View profile for Katja Lindenberg
Katja Lindenberg

Theoretical chemical physics: non-equilibrium statistical mechanics; stochastic processes; nonlinear phenomena; complex systems; condensed matter.

View profile for James McCammon
James McCammon

Statistical mechanics and computational chemistry, with applications to biological systems

View profile for Mario Molina
Mario Molina

Physical Chemistry: Gas Phase Chemical Kinetics and Photochemistry; Chemistry of Atmospheric Aerosols; Air Pollution in Megacities of the Developing World

View profile for Tadeusz Molinski
Tadeusz Molinski

Organic chemistry of marine natural products, synthesis, NMR, and biomedical applications

View profile for Ulrich Muller
Ulrich Muller

Evolution of catalytic RNAs, and the Origin of Life

View profile for Joseph O'Connor
Joseph O'Connor

Organotransition metal; organic; physical organic; bioorganometallic; synthetic; and inorganic chemistry

View profile for Stanley Opella
Stanley Opella

NMR structural studies of proteins in membranes and other supramolecular assemblies

View profile for Francesco Paesani
Francesco Paesani

Theoretical chemical physics of complex interfaces of relevance to the environment

View profile for Charles Perrin
Charles Perrin

Physical-organic chemistry: stereoelectronic effects; hydrogen bonding; isotope effects; ionic solvation; naked anions; malonic anhydrides

View profile for Robert Pomeroy
Robert Pomeroy

The application of analytical chemistry to forensic, environmental and industrial chemistry, then bridge these experiences into the classroom. This also includes the role technology and instrumentation play in discovery and problem solving.

View profile for Kimberly Prather
Kimberly Prather

Environmental, physical/analytical chemistry: gas/particle processes of tropospheric significance; mass spectrometry; laser-based analysis techniques.

View profile for Arnold Rheingold
Arnold Rheingold

Inorganic chemistry: Small-molecule crystallography, synthesis of transition metal/p-block clusters

View profile for Jeffrey Rinehart
Jeffrey Rinehart

Inorganic, materials, and magnetochemistry

View profile for Michael Sailor
Michael Sailor

Nanomaterials: porous silicon, chemical and biological sensors, biomaterials, electrochemistry

View profile for Barbara Sawrey
Barbara Sawrey

Chemical education: development of computer-based multimedia to assist student learning of complex scientific processes and concepts

View profile for Amitabha Sinha
Amitabha Sinha

Experimental physical chemistry: photochemistry; laser spectroscopy; reaction dynamics of vibrationally excited molecules

View profile for Michael Tauber
Michael Tauber

Physical chemistry; Optical and magnetic spectroscopy; Fundamental studies of charge transport and solvation; Applications to energy conversion and energy storage.

View profile for Susan Taylor
Susan Taylor

Structure, Function, Dynamics, and Localization of PKA as a Prototype for the Protein Kinase Superfamily.

View profile for Faik Tezcan
Faik Tezcan

Bioinorganic and biophysical chemistry; Metalloprotein structure, function and biosynthesis; Biomaterials

View profile for Emmanuel Theodorakis
Emmanuel Theodorakis

Synthetic, Medicinal, Bioorganic and Biological Chemistry, Methods and Strategies in Natural Products Chemistry

View profile for Mark Thiemens
Mark Thiemens

Atmospheric chemistry: physical chemistry of isotope effects; solar system formation

View profile for Navtej Toor
Navtej Toor

Structure and Function of Introns and Retroelements

View profile for Yitzhak Tor
Yitzhak Tor

Ligand-nucleic acid interactions; Antiviral and antibacterial agents; Fluorescent nucleosides and nucleotides; Cellular delivery vehicles

View profile for William Trogler
William Trogler

Inorganic chemistry: polymer chemistry; nanomaterials.

View profile for Roger Tsien
Roger Tsien

Chemical biology; design, synthesis, and application of molecular probes of biological function

View profile for Elizabeth Villa
Elizabeth Villa

Structural Cell Biology, Cryo-Electron Microscopy, Multiscale modeling

View profile for Wei Wang
Wei Wang

epigenomics, cellular reprogramming, protein recognition, computational biology, systems biology

View profile for John Weare
John Weare

Physical chemistry: calculations of the dynamics of complex systems; theoretical geochemistry

View profile for Haim Weizman
Haim Weizman

Chemical education, Bioorganic chemistry

View profile for Roy Wollman
Roy Wollman

Spatio-temporal signaling control of biological self-organization. Signaling networks in innate immunity. Microscopy; Mathematical modeling; Computational image analysis; Systems Biology.

View profile for Wei Xiong
Wei Xiong

Investigation of charge transfer mechanism in nanomaterials with novel ultrafast spectroscopies

View profile for Jerry Yang
Jerry Yang

Bioorganic Chemistry, Molecular Self-Assembly, Molecular Synthesis, Materials Chemistry, Bionanotechnology

View profile for Joel Yuen zhou
Joel Yuen zhou

Theory at the interface of chemistry, condensed matter, and materials physics

View profile for Brian Zid
Brian Zid

Gene Expression Control During Stress; mRNA Localization to Membrane-Less Compartments


Events and Seminars

02/09/2016 (Tue) at 02:00 PM
Thesis Defense
Sarah Jane Smith
Metal-Controlled Assembly of Peptide and Protein-based Engineered Biomaterials
02/12/2016 (Fri) at 11:00 AM
Inorganic Seminar
Professor Neal Mankad
Catalytic Transformations That Utilize Bimetallic Cooperativity
02/16/2016 (Tue) at 11:00 AM
Organic Seminar
Professor Ian Manners
TBA
02/19/2016 (Fri) at 04:00 PM
Inorganic Seminar
Prof. Dr. David Scheschkewitz
Functionalization and Stepwise Expansion of Stable Unsaturated Silicon Clusters (Siliconoids)
02/22/2016 (Mon) at 11:00 AM
Organic Seminar
Professor Mindy Levine
Non-Covalent Interactions for Toxicant Detection and Oil Remediation
02/29/2016 (Mon) at 11:00 AM
Organic Seminar
Professor William M. Wuest
Draining the Moat: A Natural Product-Inspired Approach to Combat Bacterial Biofilms
03/04/2016 (Fri) at 11:00 AM
Inorganic Seminar
Professor R. Tom Baker
Base Metal Catalysis Approaches to Greener Hydrofluorocarbon Synthesis
More....