Aerial view of UCSD campus looking South
Geisel Library - Nobel Laureates at UCSD
Discovery of new atmospheric reaction garners prize
Natural Sciences Building
The crystal structure of a group II intron in the pre-catalytic state
Structure of an inhibitor of hepatitis C virus protein synthesis bound to its target in the viral ribonucleic acid (RNA) genome
ANCA probe staining amyloid plaques derived from Alzheimer’s-related Aβ peptides fluoresces as green and as yellow when derived from prion proteins (PrPSC)
Generation of bio-resistive surface coatings on amyloids inhibits harmful protein-amyloid interactions associated with Alzheimer disease
Proposed schematic models of the interfacial binding surface of four different members of the Phospholipase A2 superfamily
Urey Hall and Pacific Hall
Characterization of the "inhibitor binding pocket" in the catalytic domain of the calcium-independent phospholipase A2 with residues within a 5 A raidus of the inhibitor shown
A Crystalline Singlet Phosphinonitrene: a Nitrogen Atom Transfer Agent
Drug candidate in orange envelope bound to UPPS
Possible binding modes for phospholipase A2 via its membrane interaction site, another allosteric site, and its catalytic site
Kamil Godula, an assistant professor in the Department of Chemistry and Biochemistry at UC San Diego, was named a recipient of the National Institutes of Health (NIH) Director's New Innovator Award. The Award is part of the NIH's High-Risk, High-Reward Research program that supports exceptionally creative, early career investigators who propose innovative high-impact projects. The $2.3 million multi-year New Innovator Award will support Professor Godula's research developing chemical approaches and nanotechnologies to study how spatial arrangements of glycans on cell-surface proteins encode biological information and how this information can be harnessed to control the outcomes of cellular differentiation.
The science journal, Nature, ranked UC San Diego the top institution in the U.S., and fourth in the world, for Environmental and Earth Sciences, based on published research. The rankings of institutions for high-quality science are based on the Nature Index, a weighted fractional count of articles appearing in 68 natural science journals. UC San Diego was ranked fifth in the U.S., and 14th in the world, in all science categories combined.
A team of researchers from Professor Neal Devaraj's Lab in the Department of Chemistry and Biochemistry at UC San Diego have developed a versatile new method for tagging RNA. The team used a bacterial enzyme that recognizes a specific hairpin turn in RNA to make their tagging system. Using chemical links, they developed a system that can attach a variety of molecules to PreQ on the outer curve of the hairpin turn, so that the RNA is tagged with something useful, such as fluorescent die or a molecular handle that allows the visualization within the cell. Their research article was recently published in the Journal of the American Chemical Society. To view the full research article click here
Wei Xiong, an assistant professor in the Department of Chemistry and Biochemistry at UC San Diego, has received the Defense Advanced Research Projects Agency (DARPA) 2015 Young Faculty Award (YFA). The award provides funding of up to $1 million to further Dr. Xiong's research developing new spectroscopic techniques for observing ultrafast processes in nanomaterials, more specifically, revealing the relationship between molecular conformation and charge separation dynamics in nano-energy materials by surface sensitive multidimensional spectroscopy.
UC San Diego and The Scripps Research Institute (TSRI) announced the formation of The Visible Molecular Cell Consortium (VMCC), a collaborative effort to assemble and simulate a virtual model of a cell. Rommie Amaro, professor of chemistry and biochemistry at UC San Diego and Arthur Olson, professor of molecular biology at TSRI, will jointly direct the consortium. The collaboration leverages existing strengths at both institutions to create 3D virtual cells down to the atomic level of detail. VMCC will offer fellowship funding for a dozen graduate students and postdoctoral fellows to work on collaborative projects across multiple disciplines that build bridges between the campuses. Organizers believe insights into cellular behavior gained from the collaboration will be applicable across many scientific fields. Directors' Amaro and Olson have scheduled their first workshop for Friday, October 2, 2015. Researchers interested in learning more about the consortium can direct inquiries to email@example.com.
The Department of Chemistry and Biochemistry is pleased to announce the addition of new faculty member Vicki H. Grassian, Distinguished Professor of Chemistry and Biochemisty, Nanoengineering and the Scripps Institution of Oceanography. Dr. Grassian's primary research interests include surface chemistry of environmental interfaces, heterogeneous atmospheric chemistry, climate impact of atmospheric aerosols, and environmental and health aspects of nanoscience and nanotechnology. She is currently Co-Director of the Center for Aerosol Impacts on Climate and the Environment (CAICE), a National Science Foundation Center for Chemical Innovation, a role in which she will continue at UC San Diego. Grassian is a Fellow of the American Association of the Advancement of Science, the American Chemical Society (ACS), the Royal Society of Chemistry (RSC), and AVS – a Society for the Science and Technology of Materials, Interfaces and Processing. She has received numerous awards for her research including the National ACS Award for Creative Advances in Science and Technology (2012), the Midwest ACS Award (2014) and the RSC John Jeyes Award (2014).
A team of researchers from the Tezcan Lab in the Department of Chemistry and Biochemistry at UC San Diego have successfully engineered a protein to self-assemble with metal ions and organic linkers to form the first ternary protein-based metal-organic framework (MOF). Their work introduces a new strategy for the rational design of protein crystals as well as a new class of hybrid materials that combine the ability to design, fine tune, and crystallize MOFs with the chemical and structural versatility of proteins. The new materials could be useful for protein drug delivery, new types of biocatalysts, and molecular electronic devices. The research team included Professor Akif Tezcan (Principal Investigator), Dr. Pamela Sontz, Postdoctoral Scholar, Jake Bailey (Graduate Student) and Sophia Ahn (Undergraduate Student). Their research article was published in Chemical & Engineering News and the Journal of the American Chemical Society (JACS), selected as the ACS Editors' Choice by ACS Publications Group, and the Top Most Read Article in JACS in August 2015. To view the full research article click here