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Aerial view of UCSD campus looking South

Geisel Library - Nobel Laureates at UCSD

Discovery of new atmospheric reaction garners prize

Urey Hall Addition

Pacific Hall

Natural Sciences Building

The crystal structure of a group II intron in the pre-catalytic state

Geisel Library Walk

York Hall

Structure of an inhibitor of hepatitis C virus protein synthesis bound to its target in the viral ribonucleic acid (RNA) genome

ANCA probe staining amyloid plaques derived from Alzheimer’s-related Aβ peptides fluoresces as green and as yellow when derived from prion proteins (PrPSC)

Price Center

Generation of bio-resistive surface coatings on amyloids inhibits harmful protein-amyloid interactions associated with Alzheimer disease

Proposed schematic models of the interfacial binding surface of four different members of the Phospholipase A2 superfamily

Urey Hall and Pacific Hall

Characterization of the "inhibitor binding pocket" in the catalytic domain of the calcium-independent phospholipase A2 with residues within a 5 A raidus of the inhibitor shown

A Crystalline Singlet Phosphinonitrene: a Nitrogen Atom Transfer Agent

Mayer Hall

Drug candidate in orange envelope bound to UPPS

Possible binding modes for phospholipase A2 via its membrane interaction site, another allosteric site, and its catalytic site


Prather Research Group Embarks on CalWater 2015 Field Campaign
UC San Diego Department of Chemistry and Biochemistry Distinguished Chair in Atmospheric Chemistry Professor Kimberly Prather, CalWater 2015 Project Co-Lead, and the Prather Research Group (PRG), embarked on the CalWater 2015 field campaign to study how California gets its precipitation. CalWater 2015 is an interagency/interdisciplinary group composed of researchers from the National Oceanic Atmospheric Administration (NOAA), the U.S. Department of Energy (DOE), NASA, UC San Diego and the Scripps Institution of Oceanography. CalWater 2015 will utilize 4 aircraft, a research vessel and the Bodega Bay Marine Lab to study the impact aerosols have on precipitation levels of atmospheric rivers crossing California.

Thiemens Research Group Reveals Mars' Climate 4 Billion Years Ago
In a collaborative study, scientists from Thiemens Research Group in the Department of Chemistry and Biochemistry at the University of California, San Diego, NASA and the Smithsonian Institution, conducted new analyses of the Martian meteorite, ALH84001, discovered in Antarctica in 1984. Researchers recorded detailed measurements of carbonate minerals contained in the meteorite that revealed a record of the climate on Mars billions of years ago. The research article was published in the Proceedings of the National Academy of Sciences January 13, 2015 issue. For the full report click here

Tezcan Lab Designs Supramolecular Protein Assembly with In Vivo Enzymatic Activity
Researchers from the Tezcan Lab in the Department of Chemistry and Biochemistry at UC San Diego reported the first designed supramolecular protein assembly with a non-natural architecture that displays enzymatic activity inside living cells. Postdoctoral researcher, Dr. Woon Ju Song and Professor Akif Tezcan engineered a monomeric redox protein, through the introduction of metal-driven mutations, into a tetrameric metallo-protein. This artificial protein assembly displayed beta-lactamase activity, the primary mechanism of antibiotic resistance, and enabled bacterial cells to survive antibiotic treatment. The Tezcan Lab findings form an important bridge between protein design, synthetic biology and protein evolution. The research was published in the journal Science (12/19/2014 issue) and was funded by the National Science Foundation. For the complete research article click here

Prather Research Group Featured in Environmental Journal: High Country News
UC San Diego Professor of Chemistry & Biochemistry Kim Prather and the Prather Research Group (PRG) CalWater-2 research project characterizing marine aerosols and precipitation chemistry at the Bodega Marine Laboratory in Bodega Bay, CA are featured in the December issue of environmental magazine High Country News (HCN). The article, entitled "The Dust Detectives," is the cover story and chronicles a day in the field with Prather and her research team. PRG field experiments indicated atmospheric rivers passing over California containing dust particles from China's Taklamakan Desert dropped 40% more precipitation on California than those without the Asian dust, and that the bacteria riding on these dust particles are the likely catalysts for ice nucleation and higher precipitation levels.

Wollman Lab Researchers Determine Dynamic Responsiveness of Biochemical Signaling Networks
Professor Roy Wollman's Lab in the Department of Chemistry and Biochemistry at UC San Diego conducts research aimed at understanding biological signaling networks and the underlying principles that govern signal transduction. In a recently completed collaborative study, the Wollman Lab, along with researchers from UCLA, UC Davis, the San Diego Center for Systems Biology, and UC San Diego's Bioengineering Department and BioCircuits Institute, determined signaling dynamics enable cells to effectively distinguish signals from extrinsic noise substantially increasing the accuracy of biochemical signaling networks. Their research has been published in the journal Science (12/12/14 Issue) and was also featured in the online edition of The San Diego Union Tribune on 12/12/14. For complete research article click here

David John Lee to Receive 2014 Bruno Zimm Award
Congratulations to graduate student David John Lee (Burkart lab) for being selected as the 2014 Bruno Zimm Award Recipient! The award recognizes research excellence in the field of biophysical chemistry. This prestigious award provides a prize of $1,000.

Congratulations to the 2015 Recipient of the Silagi Undergraduate Award
Congratulations to Rhiannon M. Kennard (nominated by Dr. Michael Sailor) for being selected as the 2015 recipient of the Selma and Robert Silagi Award for Undergraduate Excellence! This annual award honors the top graduating undergraduate in the Divisions of Physical and Biological Sciences.

Tukey Researchers Find Liquid Soap Additive Causes Cancer
Researchers from Professor Robert Tukey's Superfund Research Center (SRC) at UC San Diego in collaboration with Professor Bruce Hammock's SRC at UC Davis have determined long-term exposure to Triclosan, an antimicrobial commonly found in soaps, shampoos, toothpastes and many other household items causes liver fibrosis and cancer in laboratory mice. The team's research was featured in the online editions of Time magazine on 11/17/14 and Chemical & Engineering News on 11/24/14; and their research paper has been published in the 11/17/14 early edition of the Proceedings of the National Academy of Sciences. For complete research article click here here

2014-15 Teddy Traylor Award Recipients Announced
The Department of Chemistry and Biochemistry is pleased to announce the recipients of the 2014-15 Teddy Traylor Award: Lisa Adamiak (Gianneschi Lab), Mark Boerneke (Hermann Lab), Matt Sampson (Kubiak Lab), Sam Doyle (Tauber Lab), Jessie Peters (Toor Lab).

UC San Diego's ACSSA Receives Outstanding Student Chapter Award
The Department of Chemistry and Biochemistry is proud to announce that for the second consecutive year UC San Diego's American Chemical Society Student Affiliate (UCSD ACSSA) has received the American Chemical Society's Outstanding Student Chapter Award. The award recognizes UCSD ACSSA for its outstanding programs and activities conducted during the 2013-2014 academic year.


Message from the Chair

Seth M. Cohen, Chair

Faculty Spotlight

View profile for Kim Albizati
Kim Albizati

Chemical Education

View profile for Rommie E. Amaro
Rommie E. Amaro

Computational Chemistry and Biophysics

View profile for Timothy Baker
Timothy Baker

Macromolecular, cryoelectron microscopy and three-dimensional, image-reconstruction techniques.

View profile for Stacey Brydges
Stacey Brydges

Chemical Education: Development of context-rich curriculum; Use of collaborative learning strategies in large lectures; Communication of chemistry

View profile for Michael Burkart
Michael Burkart

Natural product synthesis/biosynthesis, Biological chemistry and enzymology, Metabolic engineering.

View profile for Thomas Bussey
Thomas Bussey

Chemical Education: Visual Literacy in Science, Biochemistry Education, Nano Science Education, K-20 Professional Development, and STEM Career Development

View profile for Seth Cohen
Seth Cohen

Bioinorganic and coordination chemistry. Metalloprotein inhibitors and supramolecular materials.

View profile for Robert Continetti
Robert Continetti

Dissociation dynamics of transient species, three-body reaction dynamics, novel mass-spectrometric methods

View profile for John Crowell
John Crowell

Materials chemistry, surface kinetics of metals/semiconductors, CVD, photo-induced deposition, thin-film spectroscopy.

View profile for Edward Dennis
Edward Dennis

Biochemistry: phospholipase A2, signal transduction in macrophages, lipid maps, prostaglandin regulation, mass spec of lipids and proteins.

View profile for Neal Devaraj
Neal Devaraj

Biomimetic Chemistry, Molecular Imaging, Electrochemistry

View profile for Jack Dixon
Jack Dixon

Protein Tyrosine Phosphatase, Dual=specific Phosphatase, PTEN

View profile for Daniel Donoghue
Daniel Donoghue

Fibroblast Growth Factor Receptors (FGFRs) in Human Cancer

View profile for Josh Figueroa
Josh Figueroa

Inorganic and Organometallic Chemistry: Synthesis, Small Molecule Activation and New Transformations.

View profile for Marye Anne Fox
Marye Anne Fox

Physical organic chemistry; photochemistry; nanoscience of organized arrays.

View profile for Misha Galperin
Misha Galperin

Electron Transport in Condensed Phases. Dissipation and Relaxation Processes. Non-equilibrium Open Quantum Systems. Molecular Electronics.

View profile for Gouri Ghosh
Gouri Ghosh

Biochemistry and biophysics: transcription, signaling, pre-mRNA splicing, mRNA transport, protein-protein, protein-DNA and protein-RNA interactions

View profile for Partho Ghosh
Partho Ghosh

Mechanisms of bacterial and protozoan pathogenesis, and host response against infectious microbes.

View profile for Nathan Gianneschi
Nathan Gianneschi

Bioorganic chemistry, Supramolecular Chemistry, Bionanotechnology, Materials, Synthesis

View profile for Kamil Godula
Kamil Godula

Nanotechnologies for analysis of glycan function during development. Glycomaterials for stem cell-based tissue regeneration.

View profile for Carlos Guerrero
Carlos Guerrero

Chemical synthesis; synthesis-oriented organic chemistry; methods development; synthesis design; total synthesis of natural products.

View profile for Thomas Hermann
Thomas Hermann

RNA as a Drug Target.

View profile for Patricia Jennings
Patricia Jennings

Biophysical chemistry: protein structure, dynamics and folding; 2, 3 and 4D NMR spectroscopy; PCR; equilibrium and kinetic-fluorescence, absorbance and circular dichroism spectroscopies

View profile for Simpson Joseph
Simpson Joseph

Molecular Mechanism of Protein Synthesis

View profile for Judy Kim
Judy Kim

Biophysical chemistry: Spectroscopic studies of membrane protein folding and dynamics

View profile for Elizabeth Komives
Elizabeth Komives

Structure, function, dynamics and thermodynamics of protein-protein interactions: NMR, mass spectrometry and kinetics

View profile for Clifford Kubiak
Clifford Kubiak

Inorganic, materials, and physical chemistry: electron transfer, catalysis, fixation and utilization of carbon dioxide.

View profile for Andrew Kummel
Andrew Kummel

STM/STS of gate oxides on compound semiconductors and adsorbates on organic semiconductor

View profile for Katja Lindenberg
Katja Lindenberg

Theoretical chemical physics: non-equilibrium statistical mechanics; stochastic processes; nonlinear phenomena; complex systems; condensed matter.

View profile for J. Andrew McCammon
J. Andrew McCammon

Statistical mechanics and computational chemistry, with applications to biological systems

View profile for Mario Molina
Mario Molina

Physical Chemistry: Gas Phase Chemical Kinetics and Photochemistry; Chemistry of Atmospheric Aerosols; Air Pollution in Megacities of the Developing World

View profile for Tadeusz Molinski
Tadeusz Molinski

Organic chemistry of marine natural products, synthesis, NMR, and biomedical applications

View profile for Uli Müller
Uli Müller

Evolution of catalytic RNAs, and the Origin of Life

View profile for Joseph O
Joseph O'Connor

Organotransition metal; organic; physical organic; bioorganometallic; synthetic; and inorganic chemistry

View profile for Stanley Opella
Stanley Opella

NMR structural studies of proteins in membranes and other supramolecular assemblies

View profile for Francesco Paesani
Francesco Paesani

Theoretical chemical physics of complex interfaces of relevance to the environment

View profile for Charles Perrin
Charles Perrin

Physical-organic chemistry: stereoelectronic effects; hydrogen bonding; isotope effects; ionic solvation; naked anions; malonic anhydrides

View profile for Robert Pomeroy
Robert Pomeroy

The application of analytical chemistry to forensic, environmental and industrial chemistry, then bridge these experiences into the classroom. This also includes the role technology and instrumentation play in discovery and problem solving.

View profile for Kimberly Prather
Kimberly Prather

Environmental, physical/analytical chemistry: gas/particle processes of tropospheric significance; mass spectrometry; laser-based analysis techniques.

View profile for Arnold Rheingold
Arnold Rheingold

Inorganic chemistry: Small-molecule crystallography, synthesis of transition metal/p-block clusters

View profile for Jeffrey Rinehart
Jeffrey Rinehart

Inorganic, materials, and magnetochemistry

View profile for Michael Sailor
Michael Sailor

Nanomaterials: porous silicon, chemical and biological sensors, biomaterials, electrochemistry

View profile for Barbara Sawrey
Barbara Sawrey

Chemical education: development of computer-based multimedia to assist student learning of complex scientific processes and concepts

View profile for Amitabha Sinha
Amitabha Sinha

Experimental physical chemistry: photochemistry; laser spectroscopy; reaction dynamics of vibrationally excited molecules

View profile for Michael Tauber
Michael Tauber

Physical chemistry; Optical and magnetic spectroscopy; Fundamental studies of charge transport and solvation; Applications to energy conversion and energy storage.

View profile for Susan Taylor
Susan Taylor

Structure, Function, Dynamics, and Localization of PKA as a Prototype for the Protein Kinase Superfamily.

View profile for Akif Tezcan
Akif Tezcan

Bioinorganic and biophysical chemistry; Metalloprotein structure, function and biosynthesis; Biomaterials

View profile for Emmanuel Theodorakis
Emmanuel Theodorakis

Synthetic, Medicinal, Bioorganic and Biological Chemistry, Methods and Strategies in Natural Products Chemistry

View profile for Mark Thiemens
Mark Thiemens

Atmospheric chemistry: physical chemistry of isotope effects; solar system formation

View profile for Navtej Toor
Navtej Toor

Structure and Function of Introns and Retroelements

View profile for Yitzhak Tor
Yitzhak Tor

Ligand-nucleic acid interactions; Antiviral and antibacterial agents; Fluorescent nucleosides and nucleotides; Cellular delivery vehicles

View profile for William Trogler
William Trogler

Inorganic chemistry: polymer chemistry; nanomaterials.

View profile for Roger Tsien
Roger Tsien

Chemical biology; design, synthesis, and application of molecular probes of biological function

View profile for Robert Tukey
Robert Tukey

Environmental toxicology: The role of environmental and chemical toxicants on gene expression

View profile for Elizabeth Villa
Elizabeth Villa

Structural Cell Biology, Cryo-Electron Microscopy, Multiscale modeling

View profile for Wei Wang
Wei Wang

epigenomics, cellular reprogramming, protein recognition, computational biology, systems biology

View profile for John Weare
John Weare

Physical chemistry: calculations of the dynamics of complex systems; theoretical geochemistry

View profile for Haim Weizman
Haim Weizman

Chemical education, Bioorganic chemistry

View profile for Jim Whitesell
Jim Whitesell

Organic chemistry: studies of stereochemistry, both in a molecular and a supramolecular sense.

View profile for Roy Wollman
Roy Wollman

Spatio-temporal signaling control of biological self-organization. Signaling networks in innate immunity. Microscopy; Mathematical modeling; Computational image analysis; Systems Biology.

View profile for Wei Xiong
Wei Xiong

Investigation of charge transfer mechanism in nanomaterials with novel ultrafast spectroscopies

View profile for Jerry Yang
Jerry Yang

Bioorganic Chemistry, Molecular Self-Assembly, Molecular Synthesis, Materials Chemistry, Bionanotechnology

Events and Seminars

Jan 26 2015 at 11:00 AM
Organic Seminar
Dr. Joel P, Schneider
Peptide-based Materials for Therapeutic Delivery
Jan 26 2015 at 2:00 pm
Special Seminar
Crick Chair Recruit Candidate Professor Qiang Cui
Mechanistic Insights from multi-scale Simulations: from Proton Pumping to Self-Assembly
Jan 28 2015 at 11:00 am
Special Seminar
The 2015 Novartis Chemical Sciences Lecture-Prof. Davids W.C. MacMillan
Photoredox Catalysis: New Reactions, Mechanisms and Applications
Jan 29 2015 at 11:00 AM
Special Seminar
Dr. Venki Ramakrishnan, Winner of 2009 Nobel Prize in Chemistry
The Use of Recent Advances in Electron Microscopy to Study Ribosome Structure
Jan 30 2015 at 11:00 am
Special Seminar
Recruit Candidate Dr. James McKone
Two-Dimensional Semiconductors for Solar Energy Storage
Feb 2 2015 at 11:00 AM
Organic Seminar
Professor Matthew L. Becker
Translationally-relevant Chemical Methods for Functionalizing Degradable Polymers
Feb 6 2015 at 11:00 AM
Inorganic Seminar
Professor Joshua Goldberger
Feb 9 2015 at 11:00 AM
Organic Seminar
Professor Ming Chen Hammond
Exploiting Riboswitches to Study and Manipulate Bacterial Signaling