Hermann, Thomas
RNA as a Drug Target.

Contact Information
Associate Professor of Chemistry and Biochemistry
Co-Director, UCSD Center for Drug Discovery Innovation

Office: Pacific Hall 5222A
Phone: 858-534-4467
Email: tch@ucsd.edu
Web: tch.ucsd.edu
Group: View group members
1996 Ph.D., Max-Planck-Institute for Biochemistry and Ludwig-Maximilians-University Munich, Germany
1992 Diploma, University of Ulm, Germany
2014 - current Co-Director, UCSD Center for Drug Discovery Innovation
2001-2005 Head, Structural Chemistry Group, Anadys Pharmaceuticals, San Diego
1999-2000 Postdoc, Memorial Sloan-Kettering Cancer Center, New York
1996-1998 Postdoc, Institut de Biologie Moleculaire et Cellulaire, CNRS, Strasbourg, France
Awards and Academic Honors
Vice Chair, Gordon Research Conference on RNA Nanotechnology
EMBO Long-Term Fellow
Otto-Hahn Medal of the Max-Planck Society, Germany
Research Interests
We are exploring the structure, function and molecular recognition of ribonucleic acid (RNA). RNA molecules participate as key players in many biological processes and adopt complex architectures that are required for function. The development of ligands that bind specifically to RNA targets opens exciting new ways to expand the existing repertoire of protein-directed therapeutics. Our research employs diverse techniques, including molecular biology, biochemistry, X-ray crystallography as well as synthetic organic chemistry.
Primary Research Area
Organic Chemistry
Interdisciplinary interests
Macromolecular Structure

Outreach Activities
Mentor and provide information on undergraduate research opportunities for underrepresented minorities in my laboratory.

Prepared the Diversity Plan ‚ÄúContributions to Diversity‚ÄĚ for the establishment of a cross-campus ORU, the Center for Drug Discovery Innovation (cDDI) at UC San Diego, which was approved in December 2013.

Member of the Executive Committee of the US Department of Education Graduate Assistance in Areas of National Need (GAANN) Fellowship Program at UC San Diego

Mentor in the UC LEADS program (Leadership Excellence through Advanced DegreeS), which prepares promising students for advanced education in the STEM fields and primarily supports undergraduate students who have experienced situations or conditions that have adversely impacted their advancement in their field of study.
Image Gallery

Discovery and Screening of New RNA Targets

Structure Determination of RNA Targets and Ligand Complexes

Design and Synthesis of New Ligands for RNA Targets
Selected Publications