Komor, Alexis
DNA damage and repair; Genome editing; Chemical biology of aging

Contact Information
Assistant Professor of Chemistry and Biochemistry

Office: Urey Hall 4120D
Phone:
Email: akomor@ucsd.edu
Web: komorlab.ucsd.edu
Education
2014 Ph.D., Chemistry, California Institute of Technology
2009 B.S., Chemistry, University of California, Berkeley
Appointments
2017-present Assistant Professor, University of California, San Diego
2014-2017 Postdoctoral Scholar, The Broad Institute of MIT and Harvard
Research Interests
Aging is a multifaceted process that is believed to be initiated by damage to various cellular macromolecules such as DNA, proteins, and lipids. However, mounting evident supports the theory that damage to DNA plays a more prominent role in aging than other macromolecules. In fact, most documented progeroid syndromes (genetic diseases with phenotypes of accelerated aging) are caused by mutations in DNA repair enzymes. The Komor lab will apply chemical biology approaches to reveal molecular relationships between DNA damage and aging. We will strive to elucidate the underlying mechanisms that connect specific DNA lesions to cellular death and senescence, the major contributors of organismal aging.
Primary Research Area
Biochemistry
Interdisciplinary interests
Bioorganic
Cellular Biochemistry

Selected Publications