Magde, Douglas
Experimental physical chemistry: photochemistry and photobiophysics; pico- and femtosecond lasers

Contact Information
Professor Emeritus

Office: Urey Hall 5202
Phone: 858-534-3199
Email: dmagde@ucsd.edu
Group: View group members
Education
1970 Ph.D., Cornell University
1963 B.S., Boston College
Awards and Academic Honors
1972-1974
Research Associate, Washington State University
1970-1972
Postdoctoral Fellow, Cornell
Research Interests
Transition metals are often used in the active site of proteins. Premier examples include the heme (iron porphyrin) proteins.

Hemoglobin is the best known heme protein. For a decade we, and others, have built upon that prior knowledge of basic biological function and chemical characterization to unravel in ever-increasing detail exactly what features of the protein control the interaction of the iron atom with small ligands. We use fast kinetic studies with nanosecond, picosecond, and now femtosecond lasers. The accompanying graph illustrates absorption spectra recorded at one picosecond intervals.

Our recent studies now involve other heme proteins, in particular those recently recognized as important in the many processes regulated by nitric oxide, specifically nitric oxide synthase and guanylate cyclase. In addition, we have broadened out interests to include biological systems that utilize cobalt chemistry, namely vitamin B12 and its relatives. This has led to a patentable drug invention.

Perhaps fortuitously, the model compounds have also turned out to be useful for studies of fundamental aspects of chemical reactivity in a liquid environment. This has now evolved past the stage of basic characterization into a new era in which we are pioneering the use of ultrafast laser kinetic measurements in conjunction with high-pressure to change liquid density at constant temperature and composition.

Primary Research Area
Physical/Analytical Chemistry
Interdisciplinary interests
Bioinorganic
Biophysics

Selected Publications