Inorganic chemistry: polymer chemistry; nanomaterials.
California Institute of Technology
Awards and Academic Honors
Elected Fellow of the American Association for the Advancement of Science
Alfred P. Sloan Fellow
Rohm and Haas Faculty Fellow
DuPont Young Faculty Fellow
Phi Beta Kappa
Research focuses on new inorganic materials for chemical, biological and environmental sensing. One project focuses on the synthesis of new photoluminescent and electroluminescent silole and silafluorene trimers (Figure 1) and conjugated polymers. These materials are being applied to detecting high explosives and environmental toxicants by fluorescence methods. This enables detection of trace particles of explosives, which have applications in forensics.
There is a need for the development of inexpensive portable electronic devices for the specific detection of toxic chemicals, such as terrorist nerve agents, as well as for monitoring gaseous pollutants. In current collaborative research with professors Kummel (Chemistry), we are exploring physical vapor deposition of discrete transition metal complexes, as well as solution deposition methods, to construct chemical field effect transistors that function as chemical sensors. This research involves the synthesis of robust metal complexes that can be solution deposited as nanoscale films across electrodes for sensing in a chemFET configuration. Surface metal coordination of the vapor analyte controls the electronic sensor response.
In addition, we are exploring template approaches for preparing uniform hollow silica and titania nanospheres in the 100-3000 nm range (Figure 2) for ultrasonic imaging and cell sensor applications.
Primary Research Area
X-ray structure of trimeric chain of tetraphenyl(silole)s bridged through silicon with vinylene groups.
Uniform hollow silica nanospheres prepared by a templated sol-gel reaction on a polymer substrate, which was removed by calcination. The scale bar is 100 nm long.
- K. K. Pohaku Mitchell, S. Sandoval, M. J. Cortes-Mateos, J. G. Alfaro, A. C. Kummel and W. C. Trogler "Self-assembled targeting of cancer cells by iron(III)-doped, silica nanoparticles", J Mater Chem B, 2014, Vol. 2, 8017-8025
- Ortac I, Simberg D, Yeh YS, Yang J, Messmer B, Trogler WC, Tsien RY, Esener SC, "Dual-porosity Hollow Nanoparticles for the Immunoprotection and Delivery of Non-human Enzymes.", Nano Lett, 2014, Vol. 14, Issue 6, 3023-32.
- Han PJ, Rheingold AL, Trogler WC, "Luminescent Tris(8-hydroxyquinolates) of Bismuth(III).", Inorg Chem, 2013, Vol. 52, Issue 20, 12033-45
- Liberman A, Wu Z, Barback CV, Viveros R, Blair SL, Ellies LG, Vera DR, Mattrey RF, Kummel AC, Trogler WC, "Color Doppler Ultrasound and Gamma Imaging of Intratumorally Injected 500 nm Iron-Silica Nanoshells.", ACS Nano, 2013, Vol. 7, Issue 7, 6367-77
- Liberman A, Martinez HP, Ta CN, Barback CV, Mattrey RF, Kono Y, Blair SL, Trogler WC, Kummel AC, Wu Z, "Hollow silica and silica-boron nano/microparticles for contrast-enhanced ultrasound to detect small tumors.", Biomaterials, 2012, Vol. 33, Issue 20, 5124-9
- Pohaku Mitchell KK, Liberman A, Kummel AC, Trogler WC, "Iron(III)-doped, silica nanoshells: a biodegradable form of silica.", J Am Chem Soc, 2012, Vol. 134, Issue 34, 13997-4003
- Sandoval S, Yang J, Alfaro JG, Liberman A, Makale M, Chiang CE, Schuller IK, Kummel AC, Trogler WC, "Europium Doped TiO(2) Hollow Nanoshells: Two-Photon Imaging of Cell Binding.", Chem Mater, 2012, Vol. 24, Issue 21, 4222-4230
- Martinez HP, Kono Y, Blair SL, Sandoval S, Wang-Rodriguez J, Mattrey RF, Kummel AC, Trogler WC, "Hard shell gas-filled contrast enhancement particles for colour Doppler ultrasound imaging of tumors.", Medchemcomm, 2010, Vol. 1, Issue 4, 266-270
- Sanchez JC, Trogler WC,"Hydrosilylation of Diynes as a Route to Functional Polymers Delocalized Through Silicon," Macromol. Chem. Phys.,(2008), 209, 1527-1540.
- Yang J, Lind JU, Trogler WC, "Synthesis of Hollow Silica and Titania Nanospheres," Chem. Mater., (2008), 20, 2875-2877.