Transcription, Epigenetics, Chromatin Biology, DNA repair
Awards and Academic Honors
OKeanos-CAPA Young Investigator Award at the Chemical and Biology Interface, CAPA
Kimmel Scholar Award, The Sidney Kimmel Foundation for Cancer Research
K99/R00 NIH Pathway to Independence Award
Career Development Program Special Fellow Award, Leukemia & Lymphoma Society
Our research interests focus on the interfaces between Chemistry and Biology. In particular, we are interested in understanding the fundamental mechanisms of transcription process and its functional interplay with epigenetic and chromatin regulation, as well as DNA lesion recognition and repair during transcription.
My group takes a multidisciplinary approach, combining structural biology, chemical biology, computational biology, biochemical, and genetic methods, to study key protein complexes involved in these processing pathways. The results will have implications for transcription regulation, DNA damage recognition and DNA repair. Moreover, understanding how cells process these DNA lesions during transcription will help us to decipher the mechanisms of drug action and resistance and pave the way for rational improvement of novel anticancer drugs.
For more details of my research, please see my lab website. http://pharmacy.ucsd.edu/labs/wang/.
- RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif. "Xu L et al", Proc Natl Acad Sci U S A, 2016, Vol. 113, Issue 44, 12426-12431
- Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions. "Walmacq C et al", Proc Natl Acad Sci U S A, 2015, Vol. 112, Issue 5, E410-419
- Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. "Wang L et al", Nature, 2015, Vol. 523, Issue 7562, 621-625
- Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity. "Xu L et al", Proc Natl Acad Sci U S A, 2015, Vol. 111, Issue 32, E3269-3276
- Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. "Wang L et al", Proc Natl Acad Sci U S A, 2014, Vol. 111, Issue 52, 18566-18571
- Effect of a monofunctional phenanthriplatin-DNA adduct on RNA polymerase II transcriptional fidelity and translesion synthesis. "Kellinger MW et al", J Am Chem Soc., 2013, Vol. 135, Issue 35, 13054-13061
- 5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription. "Kellinger MW et al", Nat Struct Mol Biol., 2012, Vol. 134, Issue 19, 8231-8240