Cellular and Systems Biochemistry
The Cellular and Systems Biochemistry Track provides an interdisciplinary and dynamic training program for graduate students in the Department of Chemistry and Biochemistry. This track draws both on traditional cellular biochemistry strengths in the department as well as recent emphasis on quantitative Systems Biochemistry. The track is designed for students who wish to receive training in the quantitative analysis of signaling networks, macromolecular behavior, cellular behavior, systems biology, and computational modeling. The BioCircuits Institute and the San Diego Center for Systems Biology have affirmed the department’s leadership in quantitative Systems Biochemistry. The NCI Training Grant in Cellular Growth and Oncogenesis and the NIH Training Grant on Heme and Blood Proteins have supported many high achieving students. The methods in this track include genomics, proteomics, transcriptomics, lipidomics, mass spectroscopy, immunochemistry, protein and nucleic acid analysis.
Course Offerings: CHEM 210 From Genomics to Metabolomics (W), CHEM 214 Molecular and Cellular Biochemistry (F), CHEM 217 RNA Structure, Function (S), and Biology, CHEM 219A/295 Special Topics in Biochemistry (F), CHEM 221 Signal Transduction (W), CHEM 250 Seminar in Chemistry (S), CHEM 264/SPPS 268 Proteomics for Biologists' (S), CHEM 280 Applied Bioinformatics (W)
Professor of Chemistry and Biochemistry
Professor of Pharmacology
Research Topics
Biochemistry: phospholipase A2, signal transduction in macrophages, lipid maps, prostaglandin regulation, mass spec of lipids and proteins.
Professor of Chemistry and Biochemistry
Professor of Pharmacology
Research Topics
Protein Tyrosine Phosphatase, Dual=specific Phosphatase, PTEN
Professor of Chemistry and Biochemistry
Chair, Academic Senate, San Diego Division, 2008/2009
Vice Chair, Graduate Education, Dept. Chemistry & Biochemistry
Program Director, NIH Training Grant
Research Topics
Fibroblast Growth Factor Receptors (FGFRs) in Human Cancer
Associate Professor of Chemistry and Biochemistry
Associate Professor of Pharmacology
Research Topics
Biochemistry, Chemical Biology, Mass spectrometry; Harvesting genomic information for therapeutics.
Professor of Chemistry and Biochemistry
Research Topics
Biochemistry and biophysics: transcription, signaling, pre-mRNA splicing, mRNA transport, protein-protein, protein-DNA and protein-RNA interactions
Professor of Chemistry and Biochemistry
Research Topics
Mechanisms of bacterial and protozoan pathogenesis, and host response against infectious microbes.
Professor of Chemistry and Biochemistry
Research Topics
Biochemistry: signaling, transcription, computational network; stress and immune responses, apoptosis, proliferation
Professor of Chemistry and Biochemistry
Research Topics
Biophysical chemistry: protein structure, dynamics and folding; 2, 3 and 4D NMR spectroscopy; PCR; equilibrium and kinetic-fluorescence, absorbance and circular dichroism spectroscopies
Professor of Chemistry and Biochemistry
Research Topics
Biochemistry & Biophysics: ribosome structure, function and dynamics; discovery of novel antibiotics
Professor of Chemistry and Biochemistry
Bruno Zimm Scholar
Research Topics
Structure, function, dynamics and thermodynamics of protein-protein interactions: NMR, mass spectrometry and kinetics
Assistant Professor of Chemistry and Biochemistry
Research Topics
Biochemistry: Evolution of catalytic RNAs, the Origin of Life
Professor of Chemistry and Biochemistry
Professor of Pharmacology
Howard Hughes Medical Institute
Research Topics
Structure, Function, Dynamics, and Localization of PKA as a Prototype for the Protein Kinase Superfamily.
Assistant Professor of Chemistry and Biochemistry
Research Topics
Structure and Function of Introns and Retroelements
Professor of Chemistry and Biochemistry
Professor of Pharmacology
Research Topics
Chemical biology; design, synthesis, and application of molecular probes of biological function
Professor of Chemistry and Biochemistry
Professor of Pharmacology
Research Topics
Environmental toxicology: The role of environmental and chemical toxicants on gene expression
Associate Professor of Chemistry and Biochemistry
Research Topics
Inference of gene regulatory networks and determination of protein specificity