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Aerial view of UCSD campus looking South

Geisel Library - Nobel Laureates at UCSD

Discovery of new atmospheric reaction garners prize

Urey Hall Addition

Pacific Hall

Natural Sciences Building

The crystal structure of a group II intron in the pre-catalytic state

Geisel Library Walk

York Hall

Structure of an inhibitor of hepatitis C virus protein synthesis bound to its target in the viral ribonucleic acid (RNA) genome

ANCA probe staining amyloid plaques derived from Alzheimer’s-related Aβ peptides fluoresces as green and as yellow when derived from prion proteins (PrPSC)

Price Center

Generation of bio-resistive surface coatings on amyloids inhibits harmful protein-amyloid interactions associated with Alzheimer disease

Proposed schematic models of the interfacial binding surface of four different members of the Phospholipase A2 superfamily

Urey Hall and Pacific Hall

Characterization of the "inhibitor binding pocket" in the catalytic domain of the calcium-independent phospholipase A2 with residues within a 5 A raidus of the inhibitor shown

A Crystalline Singlet Phosphinonitrene: a Nitrogen Atom Transfer Agent

Mayer Hall

Drug candidate in orange envelope bound to UPPS

Possible binding modes for phospholipase A2 via its membrane interaction site, another allosteric site, and its catalytic site



News

Green Chemistry Commitment
In celebration of Earth Month, the UCSD Chemistry & Biochemistry Department is pleased to announce our “Green Chemistry Commitment”. More Information...

The Xiong group, in collaboration with the Yuen-Zhou group publish paper in PNAS
The Xiong group, in collaboration with the Yuen-Zhou group and scientists at Naval Research Laboratory, reported the first coherent two-dimensional infrared (2D IR) spectroscopy of molecular polariton, in the Proceedings of the National Academy of Sciences of the United States of America. Molecular vibrational-polaritons are hybrid states between molecular vibrations and photons. While they are highly promising for new opportunities to manipulate molecular potential energy landscapes and concomitantly modify reaction pathways, amongst many others, their fundamental physical properties remain elusive. By conducting experimental and theoretical studies of 2D IR spectroscopy, this work uniquely resolves excitation of polaritons and unexpected dark states in a state-selective manner, revealing otherwise hidden interactions between them. Valuable physical insights such as existence of hidden dark states, and ultrafast interactions between darks states and bright polariton states, are unambiguously measured. These results have significant implications in harvesting the creation of molecular vibrational polaritons for novel infrared photonic devices, lasing, molecular quantum simulation, as well as new chemistry by tailoring potential energy landscapes. A graduate student Bo Xiang from Xiong group and a postdoctoral fellow Raphael Ribeiro led the experimental and theoretical efforts, respectively. More Information...

Jessica Moreton, 2nd place winner of the UCSD Grad SLAM contest
Congratulations to Jessica Moreton (Cohen lab) on placing 2nd in the UCSD Grad SLAM contest!

Mark Kalaj (Cohen lab) awarded the NDSEG
Congratulations to Mark Kalaj (Cohen lab) on being awarded the National Defense Science and Engineering Graduate Fellowship (NDSEG)!!

Congratulations to the 2018 Recipients of the NSF-GRFP!
We proudly announce that the National Science Foundation has selected Glen Junor from the Bertrand Lab, Liora Mael from the Grassian lab, Christian Seitz from the Amaro lab and Terra Sztain-Pedone from the Burkart lab in the Department of Chemistry and Biochemistry as recipients of the 2018 Graduate Research Fellowship!

Vicki Grassian elected Chair of Chemistry Section of the AAAS
Vicki Grassian has been elected Chair-Elect of the Chemistry Section of the American Association for the Advancement of Science (AAAS). She begins her term as Chair Elect on February 20th 2018 following the AAAS annual meeting. This position begins a three year chair line succession of Chair-Elect, Chair, and Retiring Chair. Vicki has been a Fellow of AAAS since 2005. The Association for the Advancement of Science is the world's largest general scientific society and publisher of the journal Science. For results of the election of AAAS officers see: More Information...

Daniela Rhodes to Give DeLuca Lecture at UC San Diego
Nanyang Technological University Professor Daniela Rhodes will deliver the Marlene A. DeLuca Lecture at the University of California San Diego on Thursday, February 22. In her lecture, entitled “G-quadruplexes: the Cinderella of Nucleic Acid Structures”, Rhodes will summarize recent evidence for the in vivo presence and function of DNA and RNA G-quadruplexes in various cellular pathways including DNA replication, gene expression and telomere maintenance. The lecture begins at 4:00 p.m. in the Leichtag Family Foundation Biomedical Research Building Auditorium (Room 107). The lecture is free and open to the public. Light refreshments before the start of the lecture.

More....




Faculty Spotlight

View profile for Amaro, Rommie
Amaro, Rommie

Computational Chemistry and Biophysics

View profile for Baker, Timothy
Baker, Timothy

Macromolecular, cryoelectron microscopy and three-dimensional, image-reconstruction techniques.

View profile for Brydges, Stacey
Brydges, Stacey

Chemical Education: Development of context-rich curriculum; Use of collaborative learning strategies in large lectures; Communication of chemistry

View profile for Burkart, Michael
Burkart, Michael

Natural product synthesis/biosynthesis, Biological chemistry and enzymology, Metabolic engineering.

View profile for Bussey, Thomas
Bussey, Thomas

Chemical Education: Visual Literacy in Science, Biochemistry Education, Nano Science Education, K-20 Professional Development, and STEM Career Development

View profile for Cohen, Seth
Cohen, Seth

Bioinorganic and coordination chemistry. Metalloprotein inhibitors and supramolecular materials.

View profile for Continetti, Robert
Continetti, Robert

Dissociation dynamics of transient species, three-body reaction dynamics, novel mass-spectrometric methods

View profile for Crowell, John
Crowell, John

Materials chemistry, surface kinetics of metals/semiconductors, CVD, photo-induced deposition, thin-film spectroscopy.

View profile for Debelouchina, Galia
Debelouchina, Galia

Chemical and spectroscopic approaches for structural biology of complex biological systems

View profile for Dennis, Edward
Dennis, Edward

Biochemistry: phospholipase A2, signal transduction in macrophages, lipid maps, prostaglandin regulation, mass spec of lipids and proteins.

View profile for Deshmukh, Lalit
Deshmukh, Lalit

Solution NMR spectroscopy, retroviruses, protein and nucleic acid biochemistry

View profile for Devaraj, Neal
Devaraj, Neal

Biomimetic Chemistry, Molecular Imaging, Chemical Biology

View profile for Dixon, Jack
Dixon, Jack

Protein Tyrosine Phosphatase, Dual=specific Phosphatase, PTEN

View profile for Donoghue, Daniel
Donoghue, Daniel

Fibroblast Growth Factor Receptors (FGFRs) in Human Cancer

View profile for Figueroa, Joshua
Figueroa, Joshua

Inorganic and Organometallic Chemistry: Synthesis, Small Molecule Activation and New Transformations.

View profile for Galperin, Michael
Galperin, Michael

Electron Transport in Condensed Phases. Dissipation and Relaxation Processes. Non-equilibrium Open Quantum Systems. Molecular Electronics.

View profile for Ghosh, Gourisankar
Ghosh, Gourisankar

Biochemistry and biophysics: transcription, signaling, pre-mRNA splicing, mRNA transport, protein-protein, protein-DNA and protein-RNA interactions

View profile for Ghosh, Partho
Ghosh, Partho

Mechanisms of bacterial and protozoan pathogenesis, and host response against infectious microbes.

View profile for Godula, Kamil
Godula, Kamil

Nanotechnologies for analysis of glycan function during development. Glycomaterials for stem cell-based tissue regeneration.

View profile for Grassian, Vicki
Grassian, Vicki

Surface science of complex environmental interfaces: heterogeneous atmospheric chemistry of sea spray and mineral dust; aerosol impacts on climate; applications and implications of nanoscience and nanotechnology.

View profile for Hermann, Thomas
Hermann, Thomas

RNA as a Drug Target and a Material for Nanotechnology

View profile for Jennings, Patricia
Jennings, Patricia

Biophysical chemistry: protein structure, dynamics and folding; 2, 3 and 4D NMR spectroscopy; PCR; equilibrium and kinetic-fluorescence, absorbance and circular dichroism spectroscopies

View profile for Joseph, Simpson
Joseph, Simpson

Molecular Mechanism of Protein Synthesis

View profile for Kim, Judy
Kim, Judy

Biophysical chemistry: Spectroscopic studies of membrane protein folding and dynamics

View profile for Klosterman, Jeremy
Klosterman, Jeremy

Playing with molecules in 3D

View profile for Komives, Elizabeth
Komives, Elizabeth

Structure, function, dynamics and thermodynamics of protein-protein interactions: NMR, mass spectrometry and kinetics

View profile for Komor, Alexis
Komor, Alexis

DNA damage and repair; Genome editing; Chemical biology of aging

View profile for Kubiak, Clifford
Kubiak, Clifford

Inorganic, materials, and physical chemistry: electron transfer, catalysis, fixation and utilization of carbon dioxide.

View profile for Kummel, Andrew
Kummel, Andrew

STM/STS of gate oxides on compound semiconductors and adsorbates on organic semiconductor

View profile for Lindenberg, Katja
Lindenberg, Katja

Theoretical chemical physics: non-equilibrium statistical mechanics; stochastic processes; nonlinear phenomena; complex systems; condensed matter.

View profile for McCammon, J. Andrew
McCammon, J. Andrew

Statistical mechanics and computational chemistry, with applications to biological systems

View profile for McHugh, Colleen
McHugh, Colleen

RNA-protein interactions; Assembly of RNPs; Structural biology of multimeric complexes

View profile for Molina, Mario
Molina, Mario

Physical Chemistry: Gas Phase Chemical Kinetics and Photochemistry; Chemistry of Atmospheric Aerosols; Air Pollution in Megacities of the Developing World

View profile for Molinski, Tadeusz
Molinski, Tadeusz

Organic chemistry of marine natural products, synthesis, NMR, and biomedical applications

View profile for Muller, Ulrich
Muller, Ulrich

Evolution of catalytic RNAs, and the Origin of Life

View profile for O'connor, Joseph
O'connor, Joseph

Organotransition metal; organic; physical organic; bioorganometallic; synthetic; and inorganic chemistry

View profile for Opella, Stanley
Opella, Stanley

NMR structural studies of proteins in membranes and other supramolecular assemblies

View profile for Paesani, Francesco
Paesani, Francesco

Theoretical chemical physics of complex interfaces of relevance to the environment

View profile for Perrin, Charles
Perrin, Charles

Physical-organic chemistry: stereoelectronic effects; hydrogen bonding; isotope effects; ionic solvation; naked anions; malonic anhydrides

View profile for Pomeroy, Robert
Pomeroy, Robert

The application of analytical chemistry to forensic, environmental and industrial chemistry, then bridge these experiences into the classroom. This also includes the role technology and instrumentation play in discovery and problem solving.

View profile for Prather, Kimberly
Prather, Kimberly

Environmental, physical/analytical chemistry: gas/particle processes of tropospheric significance; mass spectrometry; laser-based analysis techniques.

View profile for Rinehart, Jeffrey
Rinehart, Jeffrey

Inorganic, materials, and magnetochemistry

View profile for Sailor, Michael
Sailor, Michael

Nanomaterials: porous silicon, chemical and biological sensors, biomaterials, electrochemistry

View profile for Schimpf, Alina
Schimpf, Alina

Spectroscopy, Inorganic Chemistry, Nanoscale Materials

View profile for Schmidt, Valerie
Schmidt, Valerie

Organic Synthesis, Catalysis, Organometallic Synthesis, Methodology Development

View profile for Sinha, Amitabha
Sinha, Amitabha

Experimental physical chemistry: photochemistry; laser spectroscopy; reaction dynamics of vibrationally excited molecules

View profile for Tauber, Michael
Tauber, Michael

Physical chemistry; Optical and magnetic spectroscopy; Fundamental studies of charge transport and solvation; Applications to energy conversion and energy storage.

View profile for Taylor, Susan
Taylor, Susan

Structure, Function, Dynamics, and Localization of PKA as a Prototype for the Protein Kinase Superfamily.

View profile for Tezcan, Faik
Tezcan, Faik

Bioinorganic and biophysical chemistry; Metalloprotein structure, function and biosynthesis; Biomaterials

View profile for Theodorakis, Emmanuel
Theodorakis, Emmanuel

Synthetic, Medicinal, Bioorganic and Biological Chemistry, Methods and Strategies in Natural Products Chemistry

View profile for Thiemens, Mark
Thiemens, Mark

Atmospheric chemistry: physical chemistry of isotope effects; solar system formation

View profile for Toor, Navtej
Toor, Navtej

Structure and Function of Introns and Retroelements

View profile for Tor, Yitzhak
Tor, Yitzhak

Ligand-nucleic acid interactions; Antiviral and antibacterial agents; Fluorescent nucleosides and nucleotides; Cellular delivery vehicles

View profile for Wang, Wei
Wang, Wei

epigenomics, cellular reprogramming, protein recognition, computational biology, systems biology

View profile for Weare, John
Weare, John

Physical chemistry: calculations of the dynamics of complex systems; theoretical geochemistry

View profile for Weizman, Haim
Weizman, Haim

Chemical education, Bioorganic chemistry

View profile for Xiong, Wei
Xiong, Wei

Investigation of Charge Dynamics and Molecular Conformations at Interfaces

View profile for Yang, Jerry
Yang, Jerry

Bioorganic Chemistry, Molecular Self-Assembly, Molecular Synthesis, Materials Chemistry, Bionanotechnology

View profile for Yuen Zhou, Joel
Yuen Zhou, Joel

Molecular photonics: theory

View profile for Zid, Brian
Zid, Brian

Gene Expression Control During Stress; mRNA Localization to Membrane-Less Compartments


Events and Seminars

04/25/2018 (Wed) at 03:00 PM
Special Seminar
Professor Beat Fierz
Synthetic and single-molecule approaches to reveal dynamic chromatin regulation
04/26/2018 (Thu) at 03:30 PM
Thesis Defense
Kyoko Yarimizu
The role of iron in potential algal-bacterial mutualisms as related to harmful algae blooms
04/27/2018 (Fri) at 01:00 PM
Chem Ed
Dr. Derik Frantz
Rings, Radicals, and Rotors: Undergraduate Research Focused on the Synthesis of Non-Natural Organic Molecules
05/01/2018 (Tue) at 04:00 PM
Physical/Analytical Seminar
Professor Nicholas Kotov
TBA
05/07/2018 (Mon) at 04:30 PM
Special Seminar
Prof. Dr. Thomas Carell
DNA Bases beyond Watson and Crick
05/08/2018 (Tue) at 04:00 PM
Physical/Analytical Seminar
Professor Sharon Glotzer
TBA
05/14/2018 (Mon) at 11:00 AM
Organic Seminar
Professor Matthew Shoulders
TBA
More....