Hermann, Thomas
RNA as a Drug Target and a Material for Nanotechnology

Contact Information
Professor of Chemistry and Biochemistry
Founding Co-Director, UCSD Center for Drug Discovery Innovation
Associate Dean for Education and Students, Division of Physical Sciences

Office: Pacific Hall 5222A
Phone: 858-534-4467
Email: tch@ucsd.edu
Web: tch.ucsd.edu
Group: View group members
1996 Ph.D., Max-Planck-Institute for Biochemistry and Ludwig-Maximilians-University Munich, Germany
1992 Diploma, University of Ulm, Germany
2018 - current Associate Dean for Education and Students, UCSD Division of Physical Sciences
2017 - 2018 Vice Chair of Education, UCSD Department of Chemistry and Biochemistry
2014 - current Co-Director, UCSD Center for Drug Discovery Innovation
2001-2005 Head, Structural Chemistry Group, Anadys Pharmaceuticals, San Diego
1999-2000 Postdoc, Memorial Sloan-Kettering Cancer Center, New York
1996-1998 Postdoc, Institut de Biologie Moleculaire et Cellulaire, CNRS, Strasbourg, France
Awards and Academic Honors
Chair, Gordon Research Conference on RNA Nanotechnology
Vice Chair, Gordon Research Conference on RNA Nanotechnology
EMBO Long-Term Fellow
Otto-Hahn Medal of the Max-Planck Society, Germany
Research Interests
We are exploring structured RNA as (1) a drug target and a material for (2) self-assembling nano-architectures.

(1) Unique three-dimensional folds enable noncoding RNAs to participate as key players in cellular processes and provide opportunities to develop selective small molecules as inhibitors and modulators of ncRNA function. Selective ligands of ncRNA targets have a potential to expand the existing repertoire of protein-directed therapeutics. We use molecular biology and biochemistry approaches to discover and validate RNA targets, biophysical methods to study their structure and discover interactions with ligands, as well as synthetic organic chemistry to prepare and optimize RNA-binding molecules.

(2) Nucleic acid nanotechnology aims to design and build functional materials and devices that self-assemble through base pairing and folding of DNA or RNA strands. We develop crystal structure-guided design and screening approaches to create complex nucleic acid nano-architectures that self-assemble from RNA motifs as architectural joints and DNA building blocks as functional modules for modification and chemical diversification. To obtain complex soft materials, we devise additive and subtractive manufacturing techniques for self-assembling nucleic acid components.
Primary Research Area
Organic Chemistry
Interdisciplinary interests
Macromolecular Structure

Outreach Activities
Undergraduate research opportunities for underrepresented minorities.

Diversity Plan for the establishment of the Center for Drug Discovery Innovation (CDDI), a cross-campus Organized Research Unit at UC San Diego (since 2014).

Member of the Executive Committee of the US Department of Education Graduate Assistance in Areas of National Need (GAANN) Fellowship Program at UC San Diego.

Mentor in the UC LEADS program (Leadership Excellence through Advanced DegreeS), which prepares promising students for advanced education in the STEM fields and primarily supports undergraduate students who have experienced situations or conditions that have adversely impacted their advancement in their field of study.
Image Gallery

Design and Applications of Self-Assembling RNA Nanostructures

Structure Determination of RNA Targets and Ligand Complexes

Design and Synthesis of New Ligands for RNA Targets

Selected Publications