Hector Viadiu
Laboratory of Structural Biochemistry: X-ray Crystallography and Cryo-Electron Microscopy of DNA Binding Proteins and Membrane Proteins
Education
2000 Ph.D.,
Columbia University
Awards and Academic Honors
2010
NSF Career Award
2008
Hellman Award
2001-2006
Postdoctoral Fellow, Harvard Medical School
2001-2003
Damon-Runyon Fellow
1993-1998
Fulbright-CONACYT Fellow
Research Interests
Our program on Structural Biochemistry integrates high-resolution information obtained by X-ray Crystallography with Cryo-Electron Microscopy data to study DNA-binding proteins and membrane proteins.
Lab Website: http://viadiulab.weebly.com
Primary Research Area
Biochemistry
Interdisciplinary interests
Macromolecular Structure
Biophysics
Selected Publications
- Ethayathulla AS, Nguyen HT, Viadiu H, "Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elements.", J Biol Chem, 2013, Vol. 288, Issue 7, 4744-54
[View Abstract]
- Monti P, Russo D, Bocciardi R, Foggetti G, Menichini P, Divizia MT, Lerone M, Graziano C, Wischmeijer A, Viadiu H, Ravazzolo R, Inga A, Fronza G, "EEC- and ADULT-Associated TP63 Mutations Exhibit Functional Heterogeneity Toward P63 Responsive Sequences.", Hum Mutat, 2013, Vol. 34, Issue 6, 894-904
[View Abstract]
- Ethayathulla AS, Tse PW, Monti P, Nguyen S, Inga A, Fronza G, Viadiu H, "Structure of p73 DNA-binding domain tetramer modulates p73 transactivation.", Proc Natl Acad Sci U S A, 2012, Vol. 109, Issue 16, 6066-71
[View Abstract]
- Pham N, Lucumi A, Cheung N, Viadiu H, "The tetramer of p53 in the absence of DNA forms a relaxed quaternary state.", Biochemistry, 2012, Vol. 51, Issue 41, 8053-5
[View Abstract]
- Viadiu H, "Molecular architecture of tumor suppressor p53.", Curr Top Med Chem, 2008, Vol. 8, Issue 15, 1327-34
[View Abstract]
- Viadiu H, Gonen T, Walz T, "Projection map of aquaporin-9 at 7 A resolution.", J Mol Biol, 2007, Vol. 367, Issue 1, 80-8
[View Abstract]
- Vanamee ES, Viadiu H, Kucera R, Dorner L, Picone S, Schildkraut I, Aggarwal AK, "A view of consecutive binding events from structures of tetrameric endonuclease SfiI bound to DNA.", EMBO J, 2005, Vol. 24, Issue 23, 4198-208
[View Abstract]
- Viadiu H, Stemmann O, Kirschner MW, Walz T, "Domain structure of separase and its binding to securin as determined by EM.", Nat Struct Mol Biol, 2005, Vol. 12, Issue 6, 552-3
[View Abstract]
- Scully KM, Jacobson EM, Jepsen K, Lunyak V, Viadiu H, Carrière C, Rose DW, Hooshmand F, Aggarwal AK, Rosenfeld MG, "Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification.", Science, 2000, Vol. 290, Issue 5494, 1127-31
[View Abstract]
- Viadiu H, Aggarwal AK, "Structure of BamHI bound to nonspecific DNA: a model for DNA sliding.", Mol Cell, 2000, Vol. 5, Issue 5, 889-95
[View Abstract]
- Viadiu H, Aggarwal AK, "The role of metals in catalysis by the restriction endonuclease BamHI.", Nat Struct Biol, 1998, Vol. 5, Issue 10, 910-6
[View Abstract]