Bioinorganic and coordination chemistry. Metalloprotein inhibitors and supramolecular materials.
University of California, Berkeley
Awards and Academic Honors
TREE Award, Research Corporation for Scientific Advancement
Arthur C. Cope Scholar Award, American Chemical Society
Leslie E. Orgel Faculty Scholar
Fellow, American Chemical Society
Fellow, Royal Society of Chemistry
Fellow, American Association for the Advancement of Science
Roger Revelle Fellow, American Association for the Advancement of Science
CAREER Award, National Science Foundation
Cottrell Scholar Award, Research Corporation for Scientific Advancement
Chris and Warren Hellman Faculty Scholar Award
Metalloprotein Inhibitors - Bioinorganic/Medicinal Chemistry
Several metalloproteins are implicated in various diseases, including arthritis, heart disease, cancer, and others. Compounds containing ligands that chelate the catalytic metal ion in these proteins can act as effective inhibitors of potential therapeutic value. Our investigations focus on the design, synthesis, and evaluation of novel metalloprotein inhibitors based on new ligands for binding the active site metal ions.
Metal-Organic Frameworks - Inorganic/Materials Chemistry
We study the design, preparation, and properties of metal-organic frameworks (MOFs). MOFs are a fascinating new class of advanced materials that may be useful in a variety of technological applications. We use organic chemistry to modify the surface and interior of MOFs in order to tune and optimize their physical and chemical properties.
Primary Research Area
Mentor for the Alliance for Graduate Education and Professoriate (AGEP) students, University of California – Historically Black Colleges Initiative, Sloan Scholars Program, UCDC Science Policy Internship Program (SPIP)
- Yu X, Cohen SM "Photocatalytic Metal−Organic Frameworks for Selective 2,2,2-Trifluoroethylation of Styrenes", J. Am. Chem. Soc., 2016, Vol. 138, 12320-3
- Zhang Z, Nguyen HTH, Miller SA, Ploskonka A, DeCoste J, Cohen SM "polyMOFs as Water Tolerant Materials for Selective Carbon Dioxide Separations", J. Am. Chem. Soc., 2016, Vol. 138, 920-5
- Fei H, Cohen SM, "Metalation of a thiocatechol-functionalized Zr(IV)-based metal-organic framework for selective C-H functionalization.", J Am Chem Soc, 2015, Vol. 137, Issue 6, 2191-4
- Zhang Z, Nguyen HT, Miller SA, Cohen SM, "polyMOFs: A Class of Interconvertible Polymer-Metal-Organic-Framework Hybrid Materials.", Angew Chem Int Ed Engl, 2015, Vol. 54, Issue 21, 6152-7