Neal Devaraj
Biomimetic Chemistry, Molecular Imaging, Electrochemistry
Biomimetic Chemistry, Molecular Imaging, Electrochemistry
Contact Information
Assistant Professor of Chemistry and Biochemistry
Office: Urey Hall 4120D
Phone: 858-534-9539
Email: ndevaraj@ucsd.edu
Web: devarajgroup.ucsd.edu
Group: View group members
Office: Urey Hall 4120D
Phone: 858-534-9539
Email: ndevaraj@ucsd.edu
Web: devarajgroup.ucsd.edu
Group: View group members
Education
2007 PhD, Chemistry, Stanford University
2002 BS, Chemistry, MIT
2007 PhD, Chemistry, Stanford University
2002 BS, Chemistry, MIT
Appointments
2010 Inst., , Harvard Medical School
2010 Inst., , Harvard Medical School
Awards and Academic Honors
2010
NIH Career Development Award
2007
ACS Young Investigator Award
Research Interests
Our group is interested in developing and applying bioorthogonal chemistry as a tool to study problems in synthetic biology and molecular imaging.
Primary Research Area
Biochemistry
Biochemistry
Interdisciplinary interests
Bioorganic
Materials
Synthesis
Materials
Synthesis
Image Gallery
Example of a bioorthogonal reaction (tetrazine cycloaddition). This reaction can be used to tag imaging agents to the surfaces of living cancer cells
Electrode triggered chemical reaction by changing the redox state of a copper catalyst
Imaging a breast cancer xenograft in a mouse using near infrared imaging agents. To the left is the tumor visible in the GFP channel. To the right, the near infrared channel highlighting the localization of the fluorescent agent at the tumor site
Example of a bioorthogonal reaction (tetrazine cycloaddition). This reaction can be used to tag imaging agents to the surfaces of living cancer cells
Electrode triggered chemical reaction by changing the redox state of a copper catalyst
Imaging a breast cancer xenograft in a mouse using near infrared imaging agents. To the left is the tumor visible in the GFP channel. To the right, the near infrared channel highlighting the localization of the fluorescent agent at the tumor site
Selected Publications
- Budin I, Devaraj NK, "Membrane assembly driven by a biomimetic coupling reaction.", J Am Chem Soc, 2012, Vol. 134, Issue 2, 751-3 [View Abstract]
- Devaraj NK, Thurber GM, Keliher EJ, Marinelli B, Weissleder R, "Reactive polymer enables efficient in vivo bioorthogonal chemistry.", Proc Natl Acad Sci U S A, 2012, Vol. 109, Issue 13, 4762-7 [View Abstract]
- Yang J, Karver MR, Li W, Sahu S, Devaraj NK, "Metal-catalyzed one-pot synthesis of tetrazines directly from aliphatic nitriles and hydrazine.", Angew Chem Int Ed Engl, 2012, Vol. 51, Issue 21, 5222-5 [View Abstract]
- Devaraj NK, Weissleder R, "Biomedical applications of tetrazine cycloadditions.", Acc Chem Res, 2011, Vol. 44, Issue 9, 816-27 [View Abstract]
- Devaraj NK, Hilderbrand S, Upadhyay R, Mazitschek R, Weissleder R, "Bioorthogonal turn-on probes for imaging small molecules inside living cells.", Angew Chem Int Ed Engl, 2010, Vol. 49, Issue 16, 2869-72 [View Abstract]
- Haun JB, Devaraj NK, Hilderbrand SA, Lee H, Weissleder R, "Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection.", Nat Nanotechnol, 2010, Vol. 5, Issue 9, 660-5 [View Abstract]
- Devaraj NK, Upadhyay R, Haun JB, Hilderbrand SA, Weissleder R, "Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition.", Angew Chem Int Ed Engl, 2009, Vol. 48, Issue 38, 7013-6 [View Abstract]
- Collman JP, Devaraj NK, Decréau RA, Yang Y, Yan YL, Ebina W, Eberspacher TA, Chidsey CE, "A cytochrome C oxidase model catalyzes oxygen to water reduction under rate-limiting electron flux.", Science, 2007, Vol. 315, Issue 5818, 1565-8 [View Abstract]
- Devaraj NK, Dinolfo PH, Chidsey CE, Collman JP, "Selective functionalization of independently addressed microelectrodes by electrochemical activation and deactivation of a coupling catalyst.", J Am Chem Soc, 2006, Vol. 128, Issue 6, 1794-5 [View Abstract]
- Devaraj NK, Miller GP, Ebina W, Kakaradov B, Collman JP, Kool ET, Chidsey CE, "Chemoselective covalent coupling of oligonucleotide probes to self-assembled monolayers.", J Am Chem Soc, 2005, Vol. 127, Issue 24, 8600-1 [View Abstract]